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Published online 2015 Oct 25

In sum, given the central importance of chaperones in protein homeostasis, or proteostasis, they may serve as rational targets for the design of therapeutic strategies in neurodegenerative diseases associated with aberrant protein folding including PD

Under the ENHANCED track ( 425.600(a)(3) and 425.610), with the highest level of risk and potential reward under the Shared Savings Program, an ACO may share in savings at a sharing rate of up to 75 percent ( 425.610(d)), not to exceed 20 percent of updated benchmark ( 425.610(e)), and may share in losses at a loss sharing rate not less than 40 percent and not to exceed 75 percent ( 425.610(f)), capped at 15 percent of updated benchmark ( 425.610(g))

This extended taper is appropriate only for unusually severe responses