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The absence of liver toxicity with orforglipron, despite its primary route of elimination through hepatic CYP3A-mediated metabolism, suggests that the hepatotoxicity observed with danuglipron and lotiglipron was related to the specific chemical structures of those molecules rather than to the class of small-molecule GLP-1 agonists as a whole
Others, particularly those with obesity, type 2 diabetes or other metabolic conditions, may benefit from prescription GLP-1 medications as part of a comprehensive treatment plan
doi: 10.1002/ana.26134 104 ChenSZhouMSunJGuoAFernandoRLChenYet al
However, one of the most healing agents for the gut is the amino acid glutamine because it is the major fuel source for the enteroendocrine cells
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