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Because of this role in fat metabolism, L-carnitine has become a popular supplement for those looking to improve body composition and athletic performance

IRF1 drives the expression of the transferrin receptor, promotes intracellular Fe2+ accumulation, disrupts iron homeostasis, and induces ferroptosis in cancer cells, while blocking Gln enhances this effect (92)

Symptoms, such as movement disorders and impaired cognitive function, typically develop in the fourth decade of life and progressively deteriorate over time