Because results build gradually, consistent use over several months is generally recommended before expecting noticeable improvements in the appearance of skin texture, firmness, or fine lines
On the other hand, Motus by Tonum (oral) reported about 10.4% average weight loss in human clinical trials over six months which is notable for an oral supplement platform
Riudavets M, Barba A, and Maroto P, et al (2018) Correlation between immune-related adverse events (irAEs) and efficacy in patients with solid tumors treated with immune-checkpoints inhibitors (ICIs) J Clin Oncol 36 (15_suppl) 3064 89
Interestingly, glutamine can activate mTORC1 in a Rag-independent manner, but also activate mTORC1 indirectly by facilitating uptake of leucine, which the regulator can be exchanged with in order for activation to occur (Jewell et al., 2015)