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In December 2025, the BBB National Programs' National Advertising Division said Willow had not established a reasonable basis for certain challenged advertising claims and recommended that the claims be modified or discontinued

The influence on the BPC-157 dopamine system, in particular, may explain some of the behavioral effects observed in animal studies, including antidepressant-like and anxiolytic-like activities

Markey KA, Mollan SP, Jensen RH, Sinclair AJ