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For laboratory reconstitution of lyophilized research compounds, bacteriostatic water is generally preferred when multiple doses or draws are needed from a single vial

DOI: Published online: June 30, 2021 Department of Anesthesiology and Pain Medicine, Dong-A University College of Medicine, Busan, Korea Corresponding Author: Tae Young Lee, Department of Anesthesiology and Pain Medicine, Dong-A University College of Medicine, 26, Daeshingongwon-ro, Seo-gu, Busan 49201, Korea, Tel: +82-51-240-5390 Fax: +82-51-247-7819 E-mail: [email protected] Received: June 24, 2020 Revised: October 3, 2020 Accepted: October 28, 2020 Copyright 2021 by Korean Association of Medical Journal Editors Articles published in Kosin Medical Journal are open-access, distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited

Because the hinge and latch hypothesis predicts that the wild-type-mutant heterodimer does not support Nrf2 ubiquitination, a heterozygous missense mutation would result in the 75% reduction of Keap1 activity

OTC products cannot be tailored to these genetic differences, whereas prescription options allow providers to adjust dosing and formulation based on individual response patterns