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There is some evidence that GLP-1s might decrease collagen and moisture levels in the skin, for example, by turning off adipose-derived stem cells which, would otherwise stimulate fibroblasts in the skin to produce collagen, elastin, and hyaluronic acid, Steven Dayan, MD, a board-certified plastic surgeon in Chicago who has researched the impact of GLP-1s on skin, has told Allure

When sleep quality declines, stress hormones such as cortisol may increase, which can make the body more sensitive to nausea or gastrointestinal discomfort