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The Phase 3 data at 68 weeks showed continued weight loss at a rate that suggested the plateau, if it exists, lies beyond 68 weeks

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However, a recent meta-analysis of 14 randomized, placebo-controlled trials in 2,149 participants with heart failure found that supplemental coenzyme Q 10 (30-300 mg/day) resulted in a 39% reduction in mortality (seven studies), improved exercise capacity (four studies), but had no effect on left ventricular ejection fraction (nine studies) compared to placebo (34)