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Additionally, transient receptor potential cation channel 6 (TRPC6)-mediated ERK1/2 activation enhances the resistance of dentate granule cells to status epilepticus by promoting LONP1 expression, indicating that LONP1 may act as a critical node in neuronal excitability regulatory networks [91]

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Consideration in the design of effective nano herbal formulation of novel phytoconstituents comprises understanding the cell signaling pathway in the origin and progress of CKD, followed by its inhibition in altering the disease condition (inflammation, oxidative stress, and fibrosis)

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