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IHC staining also demonstrated that the protein contents of ABCA1 and GLP-1 decreased in T2DM and T2DM + sham groups while it increased in T2DM + RYGB and T2DM + EX-4 groups (Figures 7B,C)

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Rapid weight loss from caloric deficit can mobilize both fat and muscle for energy, especially if protein intake or resistance exercise are inadequate