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This washout period allows semaglutide to be eliminated from the body, as the medication has a half-life of approximately one week, with steady-state concentrations achieved after 45 weeks of regular dosing

Neuroscience 147 (1), 136145

So we thought it only appropriate to give an update on the obesity field (see previous posts here)

[5] On top of the vascular/NO layer sits the neuromodulatory extension discussed earlier: reported interactions with dopaminergic, serotonergic, and GABAergic systems, largely interpreted through the braingut axis