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In hepatocellular carcinoma (HCC), LCACs are effectively loaded into the mitochondria of lymphocytes, resulting in the inhibition of invariant natural killer T (iNKT) cell expansion and the promotion of their senescence while simultaneously facilitating tumor evasion of immune surveillance [66]

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In all these cases, the underlying issue is the overactivity of melanin pathways , which leads to darker patches compared to the surrounding skin

in particular mitochondrial donation rescued dopaminergic neurones