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Disruption of GLP-1 secretion rhythm Besides L-cells biological rhythms regulating GLP-1 release, dietary structure, obesity, prolonged light exposure, sleep disorders, and intestinal flora disorders can affect the rhythmic secretion of GLP-1

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First, hyperhomocysteinemia detected only in the fasting state (approximately 23% of patients), which might mainly result from an inhibition of the homocysteine remethylation pathway (folate, cobalamin, or functional methionine synthase deficiencies or thermolabile MTHFR mutation), and which increases the cardiovascular risk 1.6-fold