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Two routes of iron accumulation in astrocytes: ascorbate-dependent ferrous iron uptake via the divalent metal transporter (DMT1) plus an independent route for ferric iron

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Mazdutide currently faces clear clinical limitations: Lack of Broad Demographic Validation: While its 20% weight reduction in high-dose Chinese cohorts is outstanding, large-scale, global phase 3 data across diverse, multi-ethnic Western populations is still missing

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