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[55] demonstrated that obese subjects presented increased activation in appetite and reward-related brain areas in response to food images

Participants lost an average of 10-15% of their body weight over the course of a year, and many showed improvements in blood pressure and cholesterol levels

In contrast, specific to the L-cell, Gcg expression has been shown to be downstream of the canonical Wnt signaling pathway (a specific signaling transduction pathway), -catenin and transcription factor 7 like 2 (TCF7L2) (28)

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