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Mean body-weight reduction as a weekly GLP-1 agonist2.4 mg 68 wk Wilding, NEJM 2021

Studies have shown that the first-generation dual receptor agonist (DA-JC1) has neuroprotective effects on MPTP-induced PD mice

GLP-1 Medications Natural GLP-1 Produced primarily by L-cells in the small intestine Released in response to food intake, especially carbohydrates and fats Has a very short half-life (12 minutes) Levels are often reduced in patients with type 2 diabetes or obesity Production can be enhanced through dietary choices (high fiber intake, protein consumption) GLP-1 Medications (Such as Semaglutide) Synthetic molecules designed to mimic natural GLP-1 Engineered to resist enzymatic degradation Provide sustained receptor activation (hours to days) Deliver consistent therapeutic effects independent of meal timing Available in various formulations (daily or weekly injections) Provide more robust and predictable effects than relying solely on endogenous GLP-1 How GLP-1 Medications Mimic the Natural Hormone GLP-1 medications represent a remarkable achievement in biomimetic pharmacology