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In addition to the effects on fibroblasts, PRP reduces lipid peroxidation and alleviates ferroptosis in endothelial cells treated with high glucose and ferroptosis inducer Erastin, improving cell regeneration and proliferation to promote diabetic ulcer healing [80]
Under physiological conditions, the Neh2 structural domain of Nrf2 binds to Kelch-like ECH-associated protein 1 (Keap1) in the cytoplasm, facilitating Nrf2 ubiquitination and subsequent degradation ( 3.1.3 TRPM4 channels and endothelial dysfunction in atherosclerosis Ye et al
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