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Reactive oxygen species generated by leukocytes, especially polymorphonuclear leukocytes (PML), or granulocytes, can have a deleterious effect on human spermatozoa, as shown by a marked loss of sperm motility and a reduced capacity for oocyte penetration

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When glutathione neutralizes a free radical, it becomes "oxidized." In this state, it is spent and cannot protect the cell anymore