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During a New Haven blizzard interrupting daily methadone treatment, some patients described eating large amounts of sugar, drinking vodka, or even recreating the ritual of heroin use by heating sugar cubes in spoons to ease withdrawal

The key finding is that GLP-1 can be detected in synovial fluid, Kragstrup said

GLP-1 medications, also called weight loss injections, are FDA-approved treatments like semaglutide and tirzepatide that help regulate appetite and blood sugar

Concurrently, pharmacological treatment has advanced significantly with the advent of GLP-1 receptor agonists (GLP-1 RAs), such as liraglutide, semaglutide and tirzepatide, which demonstrate substantial efficacy for weight loss [11,12,13,14] and are approved for obesity management [15]