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D., Franzblau, A

Any new development program would need to address the FDA's 2018 endocrine advisory committee position that GH secretagogues require long-term cardiovascular safety data given IGF-1's association with cancer risk in epidemiologic studies 21

Rapamycin-induced autophagy ameliorates GSH depletion-induced premature cell senescence It was shown that autophagy activation especially in the presence of an increasing autophagic flux inhibits the senescence of RPE cells 35,36,37,38,39