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It was found that the expression of GCH1 triggers the production of potent antioxidants BH4/BH2, which can block lipid peroxidation and ferroptosis, whether supplemented exogenously or produced endogenously
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Adenovirus experiments A cDNA encoding the NHK allele of 1-antitrpysin was cloned into an adenoviral shuttle vector downstream of a TRE-Tight promoter, and the shuttle was recombined with a backbone expressing rtTA under the RSV promoter
Elabela may regulate SIRT3-mediated inhibition of oxidative stress through Foxo3a deacetylation preventing diabetic-induced myocardial injury
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