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Portions upstream (443 bp) and downstream (338 bp) of the GDH2 gene were amplified and fused with the 5269 bp SAT1 fragment to form a disruption cassette (~6 kb) for GDH2 gene deletion (Supplementary Fig

In order to avoid hypoglycemia in patients on insulin a reduction in insulin dose may be considered, particularly in patients with good glycemic control

Galectin-3 inhibitors, such as belapectin, constitute another emerging class of antifibrotic agents that disrupt myofibroblast activation and collagen matrix organization