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I was modifying or even avoiding workouts altogether, and I started to feel disconnected from my own bodynot to mention more mentally sluggish than usual

Bonser LR, Erle DJ

As a result, increased stiffness triggers the translocation of the transcription factor co-activators Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) to the nucleus where they interact with the transcriptional enhanced associate domain (TEAD) family of transcription factors to induce gene expression [85]