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How PlexusDx Supports a More Personalized Approach PlexusDx recognizes that understanding individual peptide metabolism pathways may help provide context for GLP-1 eligibility and response

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Tirzepatide is a new class of medication that can offer eligible people living with obesity another treatment option and potentially reduce the economic impact of obesity, which is estimated to cost the NHS 6.1 billion annually. This authorisation is based on results from the phase 3 SURMOUNT-1 and SURMOUNT-2 clinical trials, which both met their co-primary endpoints of demonstrating that tirzepatide 10mg and 15mg achieved superior mean percent change in body weight from baseline and greater percentage of participants achieving body weight reductions of at least 5% compared to placebo

459 Second, inhibition of WNT secretion by targeting porcupine, a membrane-bound O-acetyltransferase, is another optional strategy