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As with other weight loss medications, suicidal thoughts or behaviors may occur in some patients

The care paradigm is starting to shift, with the understanding that its beneficial to treat metabolic health conditions before they progress to an advanced stage. The team hopes this new data can help physicians better understand and identify patients who are less likely to access obesity treatment, with challenges ranging from difficulty in obtaining care from obesity medicine practitioners to lack of formulary coverage for weight-management medications

Key indicators include hepatic function tests, oxidative stress markers (malondialdehyde, 8-OHdG), and systemic inflammation parameters

Nature 599 , 650656 (2021)