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In fact, as research in recent years clarified the central role of disordered metabolism in NAFLD, experts proposed a new name for the condition: metabolic dysfunction-associated fatty liver disease (MAFLD)

Why this trial matters: First triple hormone receptor agonist showing major Phase III weight-loss efficacy Delivers weight-loss outcomes far beyond many current therapies Suggests a potential new metabolic and obesity care benchmark Semaglutide Shows Consistent Liver Benefits in MASH In the Phase III ESSENCE study, once-weekly semaglutide 2.4 mg significantly increased rates of steatohepatitis resolution and fibrosis improvement on liver biopsy in adults with metabolic dysfunction-associated steatohepatitis (MASH), compared with placebo

Clin Transl Oncol (2020) 22(5):63146