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Meta-analyses indicate that high blood pressure is associated with an elevated risk of AD and vascular dementia (VAD), while coronary artery disease (CAD) and heart failure (HF) are linked to accelerated cognitive decline, particularly affecting memory, executive function, and processing speed

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Furthermore, when combined with anti-PD1 or anti-CTLA4 antibodies, CB-839 promotes the infiltration of effector T cells into tumors and upregulates IFN-associated gene expression, thereby enhancing the antitumor activity of these checkpoint inhibitors [199]

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