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So after the recent publication of a study indicating that statins can have a detrimental effect on GLP-1 secretion and insulin sensitivity, an important question quickly followed: should individuals on statins be concerned about these apparent effects on metabolic health

Fifty years of research

Key Takeaways Its not your fault: Rapid childhood weight gain and earlyonset obesity often reflect serious metabolic biology, including rare gene variants, growth phases, and hormone signalingnot gluttony or laziness

PKM2 also decreased the inflammatory mediators produced by IL-1 stimulation accumulation (tumor necrosis factor- and IL-6), and downregulated the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase2 (COX-2) induced by IL-1