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9326945 cover an inherent property already disclosed and protected in the original compound patent U.S Patent 6,967,208, namely a formulation comprising crystalline apixaban particles
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A dose-response study of the most promising derivatives confirmed a high potency and duration of action with an ED50 below 2 nmol/kg (calculated as the delta area under the curve [AUC] for blood glucose 48 h following subcutaneous dosing) ( The remainder of this review describes the pharmacology of liraglutide and semaglutide
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