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216 (2020): 165-172.e4

These enzymes are the rate-limiting step in the formation of prostanoids (ie, prostaglandins, thromboxane), which are involved in mediating pain and inflammation

3,4 Poor Gallbladder Function Affects Hormone Detoxification If you experience PMS or other symptoms of estrogen dominance, your gallbladder may need some attention for two key reasons: Excess estrogen increases cholesterol synthesis and reduces bile acid production