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Observed reductions in BP after 68 weeks of CagriSema treatment versus placebo were greater than those previously observed over the same time frame for semaglutide 2.4 mg in participants with overweight or obesity in the Semaglutide Treatment Effect in People with Obesity (STEP) 1, STEP 3, and STEP 4 trials, with an overall reduction in SBP versus placebo across the 3 trials of 5.0 (95% CI, 5.9 to 4.1) mm Hg

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In addition to RIDD, IRE1 also induces non-conventional splicing and activation of XBP1, a major transcription factor regulating ER homeostasis 10,66,67,68,69