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A 108 , 92059212 (2004) Rights and permissions About this article Cite this article Zhang, R., Wu, W

We propose that the requirement of two distinct glutathione interaction sites for the efficient reduction of glutathionylated disulfide substrates explains the deviating structurefunction relationships, activities and substrate preferences of different glutaredoxin subfamilies as well as thioredoxins

provides more modest weight loss (510%) with significant gastrointestinal side effects Each alternative carries distinct benefits, risks, and efficacy profiles requiring individualized discussion with healthcare providers

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