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[10] Synergy is observed when tretinoins barrier-disruptive effect is offset by niacinamide-induced ceramide synthesis, allowing maintenance of retinoid efficacy with fewer erythema and peeling events

EaglesDABoydSJKotakAAllanF.Calorie restriction of a high-carbohydrate diet elevates the threshold of Ptz-induced seizures to values equal to those seen with a ketogenic diet

The bigger message is that these agents are pushing us toward a more integrated cardiometabolic model of care, in which obesity, heart failure, kidney disease, liver disease, and vascular risk are treated as connected biology rather than as separate silos