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While these findings underscore TIPE2s role in NK cell function, they also suggest that TIPE2 plays a broader role in shaping the immunosuppressive tumor microenvironment

In subsequent studies, oral administration of HPL reversed the significant increase in Ggt1 expression elicited by OVX and promoted the efflux of the toxic levels of accumulated glutamate and its metabolites

doi: 10.1016/j.biomaterials.2014.03.062

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