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Still, sometimes I falter

The topline results from the ESSENCE trial of semaglutide showed that a once-weekly 2.4mg dose of the drug was better than placebo at resolving MASH and improving liver fibrosis, meeting its primary efficacy objectives

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Despite convincing data suggesting the central role of GLP-1R signalling in the food intake reduction effects of OXM, there were still some unexplained effects of the gut hormone including increased energy expenditure, suggesting a GLP-1R independent mechanism of action (35)