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Although it is controversial whether oxidative stress caused by mitochondrial dysfunction occurs at an early or late stage of PD ( Lewy bodies Lewy bodies (LBs) are mainly composed of aggregated presynaptic neuron protein -synuclein (-Syn), whose presence is a characteristic pathologic feature of PD

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However, payers also caution that ePA is not risk-free: automated systems must maintain data security and be updated as formularies change, else erroneous approvals could occur