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Role of superoxide anion in the generation of other reactive species Superoxide anion (O2) which is constantly being generated through endogenous processes and exogenous sources can through different pathways or chain reactions cause the formation of several other reactive species.15 It can directly produce hydroxy radical (OH) (O2 + 2e OH) or indirectly from hydrogen peroxide which results from its dismutation by SOD (H2O2 + e OH), through Fenton reaction which occurs in the presence of Fe2+ (Fig
Initial human tissue analysis revealed that FOXO4 is specifically expressed within Leydig cells of the human testis, as confirmed by its co-expression with Leydig cell markers StAR and CYP11A1 through immunofluorescent staining
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia
This activity may be driven by increased levels of brain-derived neurotrophic factor (BDNF) or through a more direct modulation of specific receptors that govern cognitive processes
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