Insulin adjustment : The MHRA has warned about the risk of diabetic ketoacidosis (DKA) when insulin is reduced or stopped when starting a GLP-1 receptor agonist
GLP-1s: Lower blood sugar Reduce appetiteso you eat less and feel fuller Promote healthy weight loss Improve metabolism Lower whole-body inflammationincluding that which affects your joints GLP-1s Target Both Metabolic and Inflammatory Pathways Recent research shows that GLP-1 medications can: Lower levels of inflammatory cytokines like TNF-alpha, IL-6, and IL-1 Restore a healthier gut microbiome and calm immune reactions Reduce fat-driven inflammationwhy losing just 510% of body weight improves autoimmune diseases Reverse insulin resistancea key link between metabolic and autoimmune disease Reduce oxidative stress, protecting organs and joint cartilage GLP-1s in RA, PsA, OA, and More: Evidence and Results Rheumatoid Arthritis Obesity increases RA risk and severity

doi: 10.1080/09546634.2020.1826392 Summary Keywords glucagon-like peptide-1, liraglutide, inflammatory diseases, immunomodulation, signal pathways Citation Chen J, Mei A, Wei Y, Li C, Qian H, Min X, Yang H, Dong L, Rao X and Zhong J (2022) GLP-1 receptor agonist as a modulator of innate immunity
What were the most striking differences