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Non-cleavable linkers typically employ highly stable covalent bonds such as thioethers and triazoles, which do not break even under acidic, reductive, or enzymatic conditions

Dominguez tends to start people on whichever medication might be most effective for a patient, rather than prescribing a less effective drug first

Many over-the-counter options contain synthetic fillers, artificial colors, or flow agents like magnesium stearate

Despite these challenges, ongoing research and advancements in analytical methods, such as the development of efficient drug measurement systems for tyrosine kinase inhibitors, suggest a promising future for TDM in oncology