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Generally, low cardiovascular risk is typically defined as the absence of cardiovascular disease and a Flemingham 10-year risk of cardiovascular events less than 20% ( Conclusion In conclusion, our meta-analysis showed that first-line use of SGLT2i and GLP-1RAs in T2DM patients at low cardiovascular disease risk significantly reduced HbA1c, body weight, and FPG levels in T2DM patients compared with placebo

This article walks through the trial-reported event frequencies, separates serious from non-serious events, and describes the dose-pause patterns described in the trial protocol and community sources

As of writing, studies in laboratory animals have not identified significant safety concerns [3, 4]