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GR protein also undergoes posttranslational modifications that regulate protein stability and function, including ubiquitination, phosphorylation, SUMOylation, and acetylation ( Figure 1 )

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As this field is rapidly evolving, and a growing number of studies support the notion that alterations in the microbiome and disease-specific pathologies occur several years before the onset of neurodegeneration, a more refined diagnostic procedure and development of novel intervention strategies (e.g., microbiome-based therapeutics) targeting the microbiome will greatly benefit translational discovery efforts in neurodegeneration

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