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Neuropathological investigations in the substantia nigra pars compacta of Parkinsons disease patients demonstrate that deficient PGC-1 expression compromises mitochondrial biogenesis and disrupts the coordinated transcriptional activation of antioxidant stress-responsive gene networks, thereby precipitating dopaminergic neuronal degeneration (Piccinin et al., 2021)

The FDA approval was based on rigorous clinical trials (the STEP trials), which showed that the benefits of the medication in reducing weight and strictly associated health risks like heart disease and diabetes generally outweigh the risks for the intended population

The trial aims to definitively test the efficacy and safety of BI 690517 given on top of standard of care, including empagliflozin