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[122] The molecule incorporates specific modifications to native GLP-1: substitution of -aminoisobutyric acid (Aib) at position 8 to confer resistance to dipeptidyl peptidase-4 (DPP-4) degradation, arginine (Arg) at position 34 for enhanced receptor affinity, and attachment of a C18 diacid fatty chain via a -glutamic acid and two O-ethylene glycol (Glu-2xOEG) spacer at lysine 26 to promote reversible binding to albumin

Toxicology 445 , 152599 (2020)

Controlling PER1 expression could be one area of investigation into naturally slowing tumor growth

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