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In the brain, GLP-1 receptor activation affects areas that regulate appetite and satiety, leading to reduced hunger and increased feelings of fullness

doi: 10.1093/hmg/dds490 17 BannisterA

The drug works as a GLP-1 receptor agonist, aiding in weight loss and maintenance when combined with diet and exercise

The REDUCE-IT trial (N=8,179), which used 4 g/day of icosapentaenoic acid ethyl ester (Vascepa), reported a higher rate of atrial fibrillation and total bleeding in the omega-3 arm, but that study used a mineral oil placebo now believed to have inflated comparative risk, and the absolute bleeding excess was small [12]