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Under such conditions marked damage to the ETC and cell death occurs following ONOO - exposure ( The effect of NO and its derivatives upon cellular GSH metabolism is also dependent on factors such as cell type, cellular environment and duration of exposure
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Cysteine is a rate-limiting precursor substrate for GSH synthesis, and its level is regulated by SLC7A11 encoding the cystine/glutamate transporter XCT, which is primarily responsible for the export of glutamine in exchange for extracellular cystine [9]
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