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Demyelination induces axonal defects, such as nodal complex alterations, conduction blocks, and/or irreversible axon losses that clearly disrupt long-range connectivity (Nave, 2010), as in multiple sclerosis (MS), an autoimmune disease targeting OLGs

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an FDA-approved active ingredient that works directly on the central nervous system by activating melanocortin receptors in the brain, unlike approaches that target the vascular system

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