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Short-chain fatty acids, acetic acid, propionic acid, and valeric acid levels were significantly different between UC patients and healthy subjects, according to a meta-analysis, and in particular, in subgroup analyses, reduced SCFA levels were likely associated with disease activity, since butyric acid levels decreased significantly only during disease activity phases (108)

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doi:10.1111/joim.12890 5

This does not detract from the importance of GABA in autism and this literature has been comprehensively reviewed in recent meta-analyses which showed that GABA levels are reduced in limbic, frontal and temporal brain regions in autism [49,50]