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Sodium glucose cotransporter 2 inhibitors in the treatment of diabetes mellitus: cardiovascular and kidney effects, potential mechanisms, and clinical applications

Our analysis indicates that there is no significant influence from unmeasured confounding variables (E-values for the point estimates [lower limits of the CI] were 2.90 [3.32), 1.54 [1.92), and 2.09 [2.39) for mortality, MACE, and MAKE, respectively)

The latter is commonly defined as a composite of cardiovascular mortality, non-fatal MI, and non-fatal stroke (i.e., 3-point MACE), which sometimes also involves uAP (i.e., 4-point MACE)