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Additionally, indole-3-carboxylic acid (ICA), a metabolite derived from Lactobacillus gallinarum , has been shown to improve anti-PD-1 efficacy in mouse models with different microsatellite instability (MSI) statuses [104]

Nature Reviews Cancer (2008) 9

When hormone-sensitive lipase is active, it cleaves the bonds holding triglycerides together, releasing fatty acids into the bloodstream where they can be oxidized for energy

Genistein administration induced Nrf2 enhancement by activation/phosphorylation of keap1, sirt1, MAPK-ERK1/2, PKC, and estrogen receptor in other cells or tissues, such as: hippocampal tissue, hypothalamic paraventricular nucleus, ovary, and Caco-2 cells [131, 135,136,137]