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Cosmetic effects: Rapid fat loss may change body appearance, sometimes making the face or body look older, though this is not a medical danger

A licensed clinician makes that determination based on your individual health profile

GLP-1 medicines are not primarily cleared by the kidneys, but the gastrointestinal side effects (nausea, vomiting, and reduced fluid intake) can cause dehydration that may strain the kidneys or trigger acute kidney injury, so staying well hydrated is important

Thus, for this top-dose being studied in the VANQUISH-1 trial, although a low n, in this Phase 1 maintenance study we will be able to identify a 31-week on-drug effect of VK2735